業績 | 東北大学大学院医学系研究科・加藤研究室

原著論文（ブログ/X/YouTube)

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2026

441. Hitomi N, Hoshi S, Kaneko MK, Kato R, Iwasaki K, Takagi J, Kato Y, Harada-Hikita A, Arimori T.
Functional and structural characterisation of a novel anti-His-tag antibody, HisMab-1
J Mol Biol, 169574, doi: 10.1016/j.jmb.2025.169574, 2025 (PDF)
440. Ubukata R, Suzuki H, Kaneko MK, Kato Y.
Development of novel anti-CDH1/E-cadherin monoclonal antibodies for flow cytometry, western blotting, and immunohistochemistry
BBREP, 45, 102401, https://www.sciencedirect.com/science/article/pii/S2405580825004881, 2025 (PDF; preprint)

2025

439. Tajiri M, Shida T, Oi R, Kondo H, Shimamoto K, Kato Y, Nogi T, Akashi S.
Characterization of two orthologues of bacterial intramembrane metalloprotease RseP by native mass spectrometry
Anal Bioanal Chem, 417(30):6865-6873, doi: 10.1007/s00216-025-06173-8, 2025 (PDF)
438. Takagi S, Tagawa M, Maekawa N, Konnai S, Kagawa Y, Hosoya K, Yamauchi A, Kudo A, Kamo S, Kim S, Kinoshita R, Deguchi T, Owaki R, Tachibana R, Yokokawa M, Takeuchi H, Nakamura H, Kato Y, Kanazawa S, Abe T, Furuta T, Yamamoto K, Suzuki Y, Okagawa T, Murata S, Ohashi K.
Clinical efficacy of anti-PD-L1 antibody HFC-L1/c4G12 in dogs with malignant tumors: an exploratory study
J Vet Med Sci., 87(12):1419-1425. doi: 10.1292/jvms.25-0303, 2025 (PDF)
437. Ohishi T, Suzuki H, Kaneko MK, Tanaka T, Harakawa A, Yoshida J, Tatsuda D, Kato Y, Kawada M.
Design and Evaluation of Eb4Mab-7-mG2a: A Dual-Action Anti-EphB4 Monoclonal Antibody for Targeted Breast Cancer Therapy
Cancer Sci, 116(12):3417-3430, doi: 10.1111/cas.70198, 2025 (PDF; preprint)
436. Hirayama A, Tanaka T, Ohishi T, Shinoda K, Nakamura T, Nomura A, Kojo N, Araki H, Suzuki K, Kaneko MK, Suzuki H, Kato Y.
Therapeutic Potential of an Anti-CD44v6 Monoclonal Antibody in Xenograft Models of Colorectal and Gastric Cancer
Cells,14(23),1873; https://doi.org/10.3390/cells14231873, 2025 (PDF; preprint)
435. Nakamura H, Konnai S, Okagawa T, Maekawa N, Tiyamanee W, Ikehata M, Matsubara K, Watari K, Kamitani K, Saito M, Kato Y, Suzuki Y, Murata S, Ohashi K.
Comprehensive Analysis of Immune Checkpoint Molecules Profiles Phenotype and Function of Exhausted T Cells in Enzootic Bovine Leukosis
J Immunol, 214(10):2600-2616, https://academic.oup.com/jimmunol/article/214/10/2600/8150973, 2025 (PDF)
434. Tanaka T, Yamamoto H, Kaneko Y, Shinoda K, Nakamura T, Li G, Fujisawa S, Satofuka H, Kaneko MK, Suzuki H, Kato Y.
Ea8Mab-9: a novel monoclonal antibody against erythropoietin-producing hepatocellular receptor A8 for flow cytometry
Microbes & Immunity, 2(4), 150–160; https://doi.org/10.36922/MI025060010, 2025 (PDF; preprint)
433. Tawara M, Suzuki H, Ohishi T, Kaneko MK, Kato Y.
Antitumor Activity by an Anti-CD44 Variant 9 Monoclonal Antibody in Gastric and Colorectal Cancer Xenograft Models
Int. J. Mol. Sci., 26(18), 9170; https://doi.org/10.3390/ijms26189170, 2025 (PDF; preprint)
432. Okada A, Suzuki H, Tanaka T, Kaneko MK, Kato Y.
Epitope Analysis of an Anti-Mouse CCR1 Monoclonal Antibody S15040E Using Flow Cytometry
Biochem Biophys Rep, 44, 102265, https://doi.org/10.1016/j.bbrep.2025.102265, 2025 (PDF; preprint)
431. Hosoya K, Kim S, Kinoshita R, Maekawa N, Konnai S, Takagi S, Tagawa M, Kagawa Y, Deguchi T, Owaki R, Tachibana Y, Yokokawa M, Takeuchi H, Nakamura H, Yamauchi A, Kudo A, Kamo S, Kato Y, Kanazawa S, Abe T, Furuta T, Yamamoto K, Suzuki Y, Okagawa T, Murata S, Ohashi K.
Exploratory, randomized, dose-response study of the anti-PD-L1 antibody HFC-L1/c4G12 in dogs with pulmonary metastatic oral malignant melanoma
Vet. Sci., 12(9), 850; https://doi.org/10.3390/vetsci12090850, 2025 (PDF)
430. Ubukata R, Ohishi T, Kaneko MK, Suzuki H, Kato Y.
EphB2-targeting monoclonal antibodies exerted antitumor activities in triple-negative breast cancer and lung mesothelioma xenograft models.
Int. J. Mol. Sci., 26(17), 8302; https://doi.org/10.3390/ijms26178302, 2025 (PDF; preprint)
429. Tiyamanee W, Okagawa T, Yamada S, Ikahata M, Nakamura H, Inoue M, Maekawa N, Kato Y, Murata S, Ohashi K, Murakami K, Konnai S.
Evaluation of PD-L1 and TIM-3 pathways in T cell during experimental BLV infection in sheep
Vet. Sci., 12(9), 810; https://doi.org/10.3390/vetsci12090810, 2025 (PDF)
428. Suzuki H, Ohishi T, Nakamura T, Yanaka M, Handa S, Tanaka T, Kaneko MK, Kato Y.
A cancer-specific anti-podocalyxin monoclonal antibody (humPcMab-60) demonstrated antitumor efficacy against human cancer xenografts
antibodies, 14(3), 67; https://doi.org/10.3390/antib14030067, 2025 (PDF; preprint)
427. Ubukata R, Suzuki H, Hirose M, Satofuka H, Tanaka T, Kaneko MK, Kato Y.
Establishment of a highly-sensitive and specific anti-EphB2 monoclonal antibody Eb2Mab-12 for Flow Cytometry
Microbes & Immunity, 2(3), 168–177, https://doi.org/10.36922/mi.5728, 2025 (PDF; preprint)
426. Haruto Yamamoto, Hiroyuki Suzuki, Tomohiro Tanaka, Mika K. Kaneko, Yukinari Kato
PMab-322: a novel anti-hippopotamus podoplanin monoclonal antibody for multiple applications
Biochem Biophys Rep, 43, 102170, https://doi.org/10.1016/j.bbrep.2025.102170, 2025 (PDF; preprint)
425. Yin AC, Holdcraft CJ, Helmig TJ, Brace EJ, Suster DI, Shienbaum AJ, Roden D, Kalyoussef E, Mir G, Capitle E, Baredes S, Shanti RM, Kaneko MK, Kato Y, Kobayashi H, Furusawa A, Fatahzadeh M, Goldberg GS.
Effects of Maackia amurensis seed lectin (MASL) on OSCC cell morphology, PDPN expression, growth, and motility in a Phase 1 clinical trial.
J Cancer Res Clin Oncol., 151(7):218. doi: 10.1007/s00432-025-06265-z., 2025 (PDF)
424. Ubukata R, Suzuki H, Tanaka T, Kaneko MK, Kato Y.
Development of an anti-CDH15/M-cadherin monoclonal antibody Ca15Mab-1 for flow cytometry, western blotting, and immunohistochemistry
Biochem Biophys Rep, 43, 1021382025, https://doi.org/10.1016/j.bbrep.2025.102138, 2025 (PDF; preprint)
423. Kaneko Y, Tanaka T, Fujisawa S, Li G, Satofuka H, Kaneko MK, Suzuki H, Kato Y.
Development of a Novel Anti-Human Glypican 5 Monoclonal Antibody (G5Mab-1) for Multiple Applications
Biochem Biophys Rep, 43, 102140, https://doi.org/10.1016/j.bbrep.2025.102140, 2025 (PDF; preprint)
422. Satofuka H, Suzuki H, Hirose M, Shinoda K, Nakamura T, Tanaka T, Kaneko MK, Kato Y.
Ea3Mab-20: A Specific Anti-Human EphA3 Monoclonal Antibody for Flow Cytometry
Biochem Biophys Rep, 43, 102130, https://www.sciencedirect.com/science/article/pii/S2405580825002171, 2025 (PDF; preprint)
421. Hosking MP, Shirinbak S, Omilusik K, Chandra S, Kaneko MK, Gentile A, Yamamoto S, Shrestha B, Grant J, Boyett M, Cardenas D, Keegan H, Ibitokou S, Pavon C, Mizoguchi T, Ihara T, Nakayama D, Abujarour R, Lee TT, Clarke R, Goodridge J, Peralta E, Maeda T, Takagi J, Arimori T, Kato Y, Valamehr B.
Preferential tumor targeting of HER2 by iPSC-derived CAR-T cells engineered to overcome multiple barriers to solid tumor efficacy
Cell Stem Cell, 32(7), 1087-1101, https://doi.org/10.1016/j.stem.2025.05.007, 2025 (PDF)
420. Mizuno T, Kato Y, Tsukui T, Igase M.
Characterization of anti-canine CD20 antibody 4E1-7-B_f and comparison with commercially available antihuman CD20 antibodies
PLoS One, 20(6):e0325526. doi: 10.1371/journal.pone.0325526, 2025 (PDF)
419. Tanaka T, Suzuki H, Taruta H, Saga A, Li G, Fujisawa S, Kaneko MK, Kato Y.
Ea1Mab-30: a novel monoclonal antibody against erythropoietin-producing hepatocellular receptor A1 for versatile applications
Monoclon. Antib. Immunodiagn. Immunother., 44(3), 41-52, DOI: 10.1089/mab.2025.0006, 2025 (PDF; preprint)
418. Tanaka T, Suzuki H, Ohishi T, Kawada M, Kaneko MK, Kato Y.
Antitumor activities by a humanized cancer-specific anti-podoplanin monoclonal antibody humPMab-117 against human tumors
Cancer Sci,116(8), 2232-2242, https://doi.org/10.1111/cas.70103, 2025 (PDF; preprint)
417. Maekawa N, Konnai S, Watari K, Takeuchi H, Nakanishi T, Tachibana T, Hosoya K, Kim S, Kinoshita R, Owaki R, Yokokawa M, Kagawa Y, Takagi S, Deguchi T, Ohta H, Kato Y, Yamamoto K, Suzuki Y, Okagawa T, Murata S, Ohashi K.
Development of caninized anti-CTLA-4 antibody as salvage combination therapy for anti-PD-L1 refractory tumors in dogs
Front. Immunol., 16, doi: 10.3389/fimmu.2025.1570717, 2025 (PDF)
416. Yamamoto H, Kaneko Y, Tanaka T, Li G, Suzuki H, Kaneko MK, Kato Y.
C8Mab-21: A Novel Anti-human CCR8 Monoclonal Antibody for Flow Cytometry
Microbes & Immunity, 2(2), 126–136, https://doi.org/10.36922/mi.4661, 2025 (PDF; preprint)
415. Satofuka H, Suzuki H, Tanaka T, Li G, Kaneko MK, Kato Y.
An Anti-Human EphA2 Monoclonal Antibody Ea2Mab-7 Shows High Sensitivity for Flow Cytometry, Western Blot, and Immunohistochemical Analyses
Biochem Biophys Rep, 42, 1019982024, 2025 (PDF; preprint)
414. Li G, Suzuki H, Tanaka T, Satofuka H, Kaneko MK, Kato Y.
A novel anti-mouse CXCR1 monoclonal antibody, Cx1Mab-8, demonstrates nanomolar affinity in flow cytometry
Biochem Biophys Rep, 42, 101965, 2025 (PDF; preprint)
413. Heydemann L, Ciurkiewicz M, Störk T, Zdora I, Hülskötter K, Gregor KM, Michaely LM, Reineking W, Schreiner T, Beythien G, Volz A, Tuchel T, Meyer Zu Natrup C, Schünemann LM, Clever S, Henneck T, von Köckritz-Blickwede M, Schaudien D, Rohn K, Schughart K, Geffers R, Kaneko MK, Kato Y, Gross C, Amanakis G, Pavlou A, Baumgärtner W, Armando F.
Persistent alveolar bronchiolization, interstitial fibrosis and impaired lung function post-exercise are features of long-COVID in SARS-CoV-2-Delta variant infected aged hamsters
Nat Commun, 16, 2080, https://www.nature.com/articles/s41467-025-57267-x, 2025 (PDF; preprint)
412. Asahi K, Hirose M, Aruga R, Shimizu Y, Tajiri M, Tanaka T, Adachi Y, Tanaka Y, Kaneko MK, Kato Y, Akashi S, Akiyama Y, Hizukuri Y, Kato T, Nogi T.
Cryo-EM structure of the bacterial intramembrane metalloprotease RseP in the substrate-bound state.
Sci Adv, 11(9), eadu0925, DOI：10.1126/sciadv.adu0925, 2025 (PDF)
411. Tanaka T, Kaneko Y, Yamamoto H, Li G, Fujisawa S, Satofuka H, Shinoda K, Nakamura T, Kaneko MK, Suzuki H, Kato Y.
Development of a novel anti-erythropoietin-producing hepatocellular receptor B6 monoclonal antibody Eb6Mab-3 for flow cytometry
Biochem Biophys Rep, 41, 101960, https://doi.org/10.1016/j.bbrep.2025.101960, 2024 (PDF; preprint)
410. Satofuka H, Suzuki H, Tanaka T, Ubukata R, Hirose M, Yamamoto H, Kaneko Y, Fujisawa S, Li G, Kaneko MK, Kato Y.
A novel Anti-Mouse CCR7 Monoclonal Antibody, C7Mab-7, Demonstrates High Sensitivity in Flow Cytometry, Western Blot, and immunohistochemistry
Biochem Biophys Rep, 41, 101948, https://doi.org/10.1016/j.bbrep.2025.101948, 2025 (PDF; preprint)
409. Liu Y, Mori T, Ito Y, Kuroki K, Hayashi S, Kohda D, Shimizu T, Ishida T, Roffler SR, Kaneko MK, Kato Y, Arimori T, Teramoto T, Takemura K, Ishibashi K, Katayama Y, Maenaka K, Kakuta Y, Kitao A, Mori T.
The strategy used by naïve anti-PEG antibodies to capture flexible and featureless PEG chains
J Control Release., 380, 396-403, doi: 10.1016/j.jconrel.2025.02.001., 2025 (PDF)
408. Ishikawa K, Suzuki H,Tanaka T,Kaneko MK, Kato Y.
Establishment of a high-affinity anti-mouse CXCR5 monoclonal antibody for flow cytometry
Microbes & Immunity, 2(1), 101–113; https://doi.org/10.36922/mi.5664, 2025 (PDF; preprint)
407. Kaneko MK, Suzuki H, Ohishi T, Nakamura T, Yanaka M, Tanaka T, Kato Y.
A Humanized Cancer-Specific anti-HER2 Monoclonal Antibody, humH2Mab-250, Exerts Antitumor Activities in Human Breast Cancer Xenograft Models
Int. J. Mol. Sci., 26(3), 1079; https://doi.org/10.3390/ijms26031079, 2025(PDF; preprint)
406. Lasota J, Kaczorowski M, Chłopek M, Miłek-Krupa J, Szczepaniak M, Ylaya K, Chodyna M, Iżycka-Świeszewska E, Scherping A, Czapiewski P, Dziuba I, Kato Y, Hałoń A, Kowalik A, Miettinen M.
An immunohistochemical and molecular genetic study of 60 colorectal carcinoma brain metastases in pursuit of predictive biomarkers for cancer therapy.
Hum Pathol.,155, 105717, https://doi.org/10.1016/j.humpath.2025.105717, 2025 (PDF)
405. Mishima Y, Okada S, Ishikawa A, Wang B, Waseda M, Kaneko MK, Kato Y, Kaneko S.
Development of chimeric antigen receptor T cells targeting cancer-expressing podocalyxin
Regen Ther., 28,292-300, https://doi.org/10.1016/j.reth.2024.12.010, 2025 (PDF)

業績(2024まで)

preprint/submit/revision/online first

業績(2024まで)

online

Li G, Tanaka T, Kaneko MK, Suzuki H, Kato Y.
Ea5Mab-7, a novel anti-EphA5 monoclonal antibody for flow cytometry and immunohistochemistry.
Microbes & Immunity, 025300066, https://doi.org/10.36922/MI025300066, 2025 (PDF; preprint)
Fujisawa S, Ubukata R, Suzuki H, Tanaka T, Nomura A, Shinoda K, Nakamura T, Satofuka H, Li G, Kaneko MK, Kato Y.
Development of novel anti-rhinoceros podoplanin monoclonal antibodies for flow cytometry, western blot, and immunohistochemistry
Microbes & Immunity, 2025 (PDF; preprint)
Tanaka T, Sakata T, Fujisawa S, Yamamoto H, Kaneko Y, Kaneko MK, Suzuki H, Kato Y.
Establishment of a novel anti-mouse CD73 monoclonal antibody C73Mab-9 by CBIS method
Microbes & Immunity, 025220048, https://doi.org/10.36922/MI025220048, 2025 (PDF; preprint)
Fujisawa S, Yamamoto H, Tanaka T, Kaneko MK, Suzuki H, Kato Y.
Development and characterization of Ea7Mab-10: a novel monoclonal antibody targeting EphA7
Microbes & Immunity, 025220049, https://doi.org/10.36922/MI0252200492025, 2025 (PDF; preprint)
Yamamoto H, Suzuki H, Tanaka T, Satofuka H, Kaneko MK, Kato Y.
Development of a novel anti-mouse CCR7 monoclonal antibody C7Mab-2 by immunization of the extracellular loop domain
Microbes & Immunity, 025130028, https://doi.org/10.36922/MI025130028, 2025 (PDF; preprint)

proof

Li G, Suzuki H, Kaneko MK, Kato Y.
Establishment of novel anti-EphB3 monoclonal antibodies for multiple applications
MAB-2025-0014, 2025 (PDF; preprint)

accept

Yamamoto H, Suzuki H, Tanaka T, Kaneko MK, Kato Y.
Development of an anti-Glypican-1 monoclonal antibody G1Mab-28 for flow cytometry, western blotting, and immunohistochemistry
Microbes & Immunity, 2025 (PDF; preprint)
Takuya Mizuno, Kei Harada, Masanao Ichimata, Ryuzo Katayama, Yukinari Kato, Toshinori Shiga, Toshihiro Tsukui, Hiroto Toyoda, Eri Fukazawa, Fukiko Matsuyama, Masaya Igase, Tetsuya Kobayashi.
Afucosylated anti-canine CD20 antibody combined with CHOP therapy in canine B-cell lymphoma
Journal of Veterinary Internal Medicine, 2025

revision

Taruta H, Tanaka T, Kaneko MK, Suzuki H, Kato Y.
Cx2Mab-5: a Novel anti-mouse CXCR2 monoclonal antibody developed by N-terminus peptide Immunization for multiple applications
MAB-2025-0017, 2025 (PDF; preprint)
Saga A, Li G, Tanaka T, Kaneko MK, Suzuki H, Kato Y.
Establishment of a novel anti-EphA4 monoclonal antibody, Ea4Mab-3, for versatile applications
Microbes & Immunity, 2025 (PDF; preprint)
Satofuka H, Suzuki H, Kaneko MK, Kato Y.
Development of anti-human cadherin-26 monoclonal antibody, Ca26Mab-6, for flow cytometry
Microbes & Immunity, 2025 (PDF; preprint)
Yoshida A, Abe S, Izumi T, Itakura S, Yamada K, Wada T, Yamamoto T, Sato C, Mitsuhashi A, Ogino H, Sato S, Shinohara T, Hanibuchi M, Kaneko MK, Kato Y, Nishioka Y.
Cancer-specific anti-human podoplanin antibody chLpMab-2f exerts antitumor effects against pleural mesothelioma
CAS, 2025
Ishii Y et al.,
MAT2A and S-adenosylmethionine are required for B cell activation through histone methylation
EMBO Molecular Medicine, 2025

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Li G, Suzuki H, Ohishi T, Satofuka H, Ishikawa K, Shimizu K, Nomura A, Araki H, Kojo N, Suzuki K, Handa S, Nakamura T, Yanaka M, Tanaka T, Kaneko MK, Kato Y.
Antitumor activities of chimeric anti-EphA2 antibodies in xenograft models of breast, pancreatic, and colorectal cancers
CAS, 2025 (PDF; preprint)
Okuno S, Suzuki H, Kaneko MK, Kato Y.
A Novel Anti-Glypican-3 Monoclonal Antibody G3Mab-25 for Flow Cytometry, Western Blotting, and Immunohistochemistry
Microbes & Immunity, DOI:10.20944/preprints202510.2209.v1, 2025 (PDF; preprint)
Sudo H, Tsuji A, Sugyo A, Kaneko MK, Kato Y, Higashi T.
Intrathoracic 90Y-NZ-16 therapy improves efficacy and reduces toxicity in pleural mesothelioma mice
Nuclear Medicine Communications, 2025
Izumi K, Furukawa E, Ishii T, Ishikawa A, Sumide K, Kaneko MK, Kato Y, Kaneko S.
Development of a Standalone Anti-PDPN CasMab CAR-T Cell Product with Tumor Specificity and Robust Antitumor Activity
Genes and Cells, 2025

preprint or in preparation

Kaneko Y, Tanaka T, Kaneko MK, Suzuki H, Kato Y.
Establishment of a Novel Anti-Human Cadherin 13 Monoclonal Antibody (Ca13Mab-4) utilizing CBIS method
Preprint, 2025 (PDF; preprint)

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