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ホーム＞研究テーマ＞脳腫瘍 脳腫瘍に対する診断法と治療法の開発   研究背景から トピックス（IDH1/2を中心に） 抗IDH抗体

マウス抗IDH1-R132H抗体；クローン名：HMab-1 MBL IBL Wako Sigma ミリポア   マウス抗IDH1-R132S抗体；クローン名：SMab-1 MBL IBL Wako Sigma ミリポア   ラット抗IDH1-R132G抗体；クローン名：GMab-r1 MBL   ラット抗IDH2-R172K抗体；クローン名：KMab-1 MBL   ラット抗IDH2-R172M抗体；クローン名：MMab-1 MBL   ラット抗IDH2-R172W抗体；クローン名：WMab-1 MBL   マウス抗変異型IDH1/2抗体；クローン名：MsMab-1 MBL Wako   マウス抗変異型IDH1/2抗体；クローン名：MsMab-2 MBL   マウス抗IDH1抗体；クローン名：RMab-3 MBL Wako ミリポア   ラット抗IDH1抗体；クローン名：RcMab-1 MBL   マウス抗IDH2抗体；クローン名：RMab-22 MBL Wako ミリポア   マウス抗IDH2抗体；クローン名：KrMab-3 MBL   ＜参考文献＞   １、Kato Y, Jin G, Kuan CT, McLendon RE, Yan H, Bigner DD   A Monoclonal Antibody IMab-1 Specifically Recognizes IDH1R132H, the Most Common Glioma-Derived Mutation.   Biochem Biophys Res Commun., 390(3), 547-551, 2009. (PDF ）   ２、 Kaneko MK, Tian W, Takano S, Suzuki H, Sawa Y, Hozumi Y, Goto K, Yamazaki K,Kitanaka C, Kato Y   Establishment of a novel monoclonal antibody SMab-1 specific for IDH1 R132S mutation.   Biochem Biophys Res Commun., 406(4), 608-613,2011 (pdf ）   ３、Takano S, Tian W, Matsuda M, Yamamoto T, Ishikawa E, Kaneko MK, Yamazaki K, Kato Y, Matsumura A   Detection of IDH1 mutation in human gliomas: comparison of immunohistochemistry and sequencing   Brain Tumor Pathology., 28(2), 115-123, 2011   ４、Preusser M, Wöhrer A, Stary S, Höftberger R, Streubel B, Hainfellner JA.   Value and Limitations of Immunohistochemistry and Gene Sequencing for Detection of the IDH1-R132H Mutation in Diffuse Glioma Biopsy Specimens.   J Neuropathol Exp Neurol. 2011 Aug;70(8):715-23.   ５、 Kwon MJ, Kim ST, Kwon MJ, Kong DS, Lee D, Park S, Kang SY, Song JY, Nam DH, Kato Y, Choi YL, Suh YL.   IDH1 mutation is a favorable prognostic factor for type 2 gliomatosis cerebri   Brain Pathol. 2011 Sep 19. doi: 10.1111/j.1750-3639.2011.00532.x. [Epub ahead of print]   ６、Takano S, Kato Y, Yamamoto T, Kaneko MK, Ishikawa E, Tsujimoto Y, Matsuda M, Nakai K, Yanagiya R, Morita S, Tsuboi K, Matsumura A.   Immunohistochemical detection of IDH1 mutation, p53 and internexin as a prognostic factor of glial tumors   J Neurooncol. 2012 Mar 7. [Epub ahead of print] 2012 Mar 7. [Epub ahead of print]   ７、 Motomura K, Natsume A, Watanabe R, Ito I, Kato Y, Momota H, Nishikawa R, Mishima K, Nakasu Y, Abe T, Namba H, Nakazato Y, Tashiro H, Takeuchi I, Mori T, Wakabayash T.   Immunohistochemical analysis-based proteomic subclassification of newly diagnosed glioblastomas with integrated genomic and epigenetic profiles   Cancer Sci., in press   ８、Kaneko MK, Tsujimoto Y, Hozumi Y, Goto K, Kato Y*.(*corresponding author)   Novel monoclonal antibodies GMab-r1 and LMab-1 specifically recognize IDH1-R132G and IDH1-R132L mutations   Monoclon. Antib. Immunodiagn. Immunother., 32(3), 224-228, 2013.   ９、Kato Y* and Kaneko MK. (*corresponding author)   Generation of a novel monoclonal antibody WMab-1 specific for IDH2-R172W mutation   Biochem Biophys Res Commun., 433(4), 374–378, 2013 （pdf）   １０、Kato Y*, Natsume A, Kaneko MK, (*corresponding author)   A novel monoclonal antibody GMab-m1 specifically recognizes IDH1-R132G mutation   Biochem Biophys Res Commun., 432(4):564-7, 2013 （pdf）   １１、Kaneko MK, Morita S, Tsujimoto Y, Yanagiya R, Nasu K, Sasaki H, Hozumi Y, Goto K, Natsume A, Watanabe M, Kumabe T, Takano S, Kato Y*(*corresponding author)   Establishment of novel monoclonal antibodies KMab-1 and MMab-1 specific for IDH2 mutations   Biochem Biophys Res Commun., 432(1):40-5, 2013 （pdf）   １２、Kaneko MK, Ogasawara S, Kato Y*. (*corresponding author)   Establishment of a novel multi-specific monoclonal antibody MsMab-1 recognizing both IDH1 and IDH2 mutations.   TJEM, 230(2), 2013   １３、Ogasawara S, Kaneko MK, Tsujimoto Y, Liu X, Kato Y*.(*corresponding author)   A Multi-specific Monoclonal Antibody MsMab-2 Recognizes IDH1-R132L and IDH2-R172M Mutations.   Monoclon. Antib. Immunodiagn. Immunother., in press   トップページに戻る